Chapter 1632: Chapter 1632

So Zhang Lin and Little Five got it right. Amazing, they know so much; they solved such a difficult case in an instant. Just now, Professor Yang also agreed with their opinion, and many doctors in the meeting room were filled with admiration for Zhang Lin and Little Five.

Is the discussion of this case over just like that?

"In fact, everyone can use the AI model from Nandu Medical University more often in the future. It can help us in many ways. If you have time, you can participate in their training sessions to understand its applications. For instance, in today’s case, artificial intelligence can be used for comparison, to identify mutated genes."

"Actually, learning it isn’t difficult. It’s just that everyone needs to have this awareness: when encountering difficult cases, one must consider the limitations of diagnostic methods. Most diagnostic methods have their scope of use, similar to the range of a measuring tool. Some difficult cases have already exceeded the range of these diagnostic methods."

Zhang Lin and Little Five, holding their microphones, spoke one after the other, coordinating seamlessly, looking very much like big shots, even impressing Director Han.

When the AI from Nandu Medical University was first introduced, many doctors thought it was unreliable, just hype. No one expected the Institute to apply it to diagnosis.

"Well, after the meeting, let’s try it out following Dr. Zhang’s suggestion. Does anyone else have any comments?" Director Bai asked the group.

Originally, everyone wanted to discuss the treatment of this case, but no matter how much they discussed it, it remained at symptomatic treatment. Dr. Zhang’s opinion clearly stated that if the pathogenic gene is found, causal treatment can be carried out. Now, discussing symptomatic treatment seems meaningless. Thɪs chapter is updated by novęlfire.net

"No need to wait until after the meeting, we can solve the problem right here and now, and also demonstrate to everyone how to use the AI model from Nandu Medical University for diagnosis. Help them with it," Yang Ping instructed Little Five and Zhang Lin.

They immediately got on the stage, with Zhang Lin holding a laptop in his hand, which had the AI model’s app on it.

"Bring out the detailed exon sequencing report, then input it into the large model. Let it help us verify one by one. It will definitely find the mutant gene, as it’s impossible for there not to be a pathogenic gene in this situation," Zhang Lin and Little Five explained as they operated.

Soon, after the report was inputted, in about ten seconds or so, the result was out. The patient carried a new mutation segment on the IL1R1 gene.

The doctors present were all astonished. It turned out that Zhang Lin and Little Five were right; there was an issue with the diagnostic method. Since the mutant gene was found, this gene is most likely the pathogenic gene. It doesn’t currently exist in the gene library, so it naturally wasn’t found during genetic diagnosis.

However, even with the result out, everyone was confused, as they didn’t recognize this gene. Moreover, clinical doctors typically lack knowledge about genes.

At this point, solid foundational knowledge once again showed its power. Zhang Lin and Little Five, due to working on Tong Yongqian’s project, had accumulated a lot of knowledge about genes, allowing them to continue following this line of thought.

IL1R1 is interleukin-1R1, does it have a defect?

Interleukin-1R1 is on the interleukin-1 signaling pathway, which is one of the key pathways in regulating the body’s inflammation and immune reactions.

Interleukin-1 and its receptor interleukin-1R1 interact to activate immunocytes, causing inflammatory reactions. The interleukin-1Ra encoded by the interleukin-1RN gene is an antagonist of this pathway, inversely regulating the inflammatory pathway.

Upon hearing this, many doctors felt their heads start to swell. These are some cutting-edge biochemical knowledge. Even if they had studied basic biochemistry well and could score a hundred on a test, it wouldn’t help now, as this involves advanced biochemical knowledge. Which doctor has the time to learn so much biochemistry?

Zhang Lin and Little Five happened to acquire a lot of knowledge in this area while researching Tong Yongqian’s case, so they could quickly think of this point and then follow this train of thought to find the mutant gene by eliminating one by one, and then confirm through some knowledge that this mutant gene is indeed the pathogenic gene.

Actually, teams in both the United States and China have vigorously researched this mutant gene and even proposed treatment methods for it.

The moment to show off has come. The two professors felt a bit excited, as this meant they not only understood the issue in diagnosis but could also cure this disease. The sense of achievement was overwhelming.

If the positive regulation factor is compared to the driving force of the inflammatory reaction, then the negative factor is the resistance. The balance between driving force and resistance is normal. Now, the driving force exceeds the resistance, causing the inflammatory reaction to accelerate wildly, which leads to autoimmune diseases.

Zhang Lin and Little Five, looking lively and confident on the platform, took turns speaking, mastering the rhythm excellently, explaining the disease mechanism clearly, evoking envy and admiration from the young doctors.

The experts on the stage nodded frequently, including Director Han, Director Tan, and Director Bai, who all nodded in satisfaction.

"Little Zhang, Little Lu! It seems everyone lacks knowledge in this area. Could you tell us if causal treatment is possible and how?" Director Han prompted Zhang Lin and Little Five.

The hint had another meaning: be mindful of the time and not talk for too long. These two were clearly showing off too much, preparing for a long talk.

"Yes, this disease can be cured, and causal treatment is possible..."

"Indeed, it can be cured using a drug that helps increase inflammatory resistance, reduces inflammatory driving force, and achieves a new balance..."

"Currently, teams at home and abroad have successfully treated this disease..."

So, what exactly is the drug? Everyone was filled with anticipation, but earlier, due to excessive excitement, both Little Five and Zhang Lin momentarily forgot the drug’s name. The name was awkward and not commonly used, making them unable to recall it.

Little Five looked at Zhang Lin, and Zhang Lin looked at Little Five, hoping the other would say the name, but no one could.

In a moment of inspiration, Little Five suggested, "Regarding this new drug, let’s consult Professor Yang, and let Professor Yang tell us."

In their urgency, Little Five handed the microphone to Yang Ping, putting the professor on the spot. If the professor’s knowledge was slightly narrower or his memory poorer, he might have gotten stuck.

"Case discussion, get to the point, just say it, what’s with the suspense," Director Han scolded Zhang Lin and Little Five mildly.

Yang Ping smiled slightly, realizing the two of them were stuck, showboating a bit too much, and then said, "Older drugs like the canakinumab targeting IL-1β can be used, or newer drugs like rilonacept, which is more effective but still experimental and might not be available."

Yes, those are the drugs. How did they momentarily forget? If not for the professor being present, they certainly couldn’t have named them. Next time, they shouldn’t both get on stage at once. One should stay in the audience at least to look up information, then provide backup to the one on stage. Showing off should alternate, not be done simultaneously.

Just after mentioning the drug name, Yang Ping’s phone vibrated. He pulled it out to see that Dean Xia was looking for him.

The old rule: Dean Xia usually lets the phone ring a few times before hanging up, which is a reminder to check WeChat. Yang Ping checked and saw Dean Xia had something urgent to discuss.

Yang Ping made a quick nod to Director Han, as Dean Xia was already waiting at the meeting room entrance.

Watching Yang Ping’s departing figure, a close call — they would have been stuck on stage in just one more minute.

"Professor Yang, let’s go to your office. Mine’s a bit noisy; the leaders from Beijing want to have a call with you, just a few words," Dean Xia said while heading towards the Institute, with Yang Ping quickly following suit.

Dean Xia’s office is still in a temporary cabin, with poor sound insulation, and it’s next to a construction site, making it indeed inconvenient for phone calls.

"The report you submitted was reviewed by the leaders above and they were very satisfied. Your report listed many bottleneck technologies in the pharmaceutical industry that need to be resolved promptly, otherwise, we risk being held back, such as vaccine adjuvants, which might seem insignificant, but without them, no vaccines can be produced," Dean Xia said while walking.

"The leaders want to directly communicate with you over the phone to hear your opinions." Dean Xia walked swiftly, creating a whirlwind, and if it weren’t for Yang Ping’s quick pace, an ordinary person wouldn’t be able to keep up with him.

PS: This case is from Professor Zhou Qing of Zhejiang University. Professor Zhou’s team is the most specialized, deep, and precise team in China for researching inflammatory genetic diseases. They not only clarified the mechanism of this disease but also invented new drugs. Salute to Professor Zhou and his team!